Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA).
نویسندگان
چکیده
Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that of the TAT transduction domain. The modified PNA recognizes and binds to the complementary DNA strand in accordance with Watson-Crick recognition rules. However, unlike polypyrimidine PNA which binds to DNA in 2:1 stoichiometry, the modified PNA binds to complementary DNA in a 1:1 ratio to form a highly stable duplex.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 125 23 شماره
صفحات -
تاریخ انتشار 2003